Gefitinib - Small Molecule (ID:10098-999)

HMS LINCS ID: 10098-999
Name: Gefitinib
Alternative Names: ZD1839; Iressa
LINCS ID: LSM-1098
PubChem CID: 123631
ChEBI ID:
ChEMBL ID:
Molecular Mass: 446.15
InChi: InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
InChi Key: XGALLCVXEZPNRQ-UHFFFAOYSA-N
SMILES: COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-07-12

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
EGFR, GAK, IRAK1
2
(equivalent to 100 nM ≤ Kd < 1µM)
ABL1, CDK7, CHEK2, CSNK1E, EPHA6, ERBB2, ERBB3, ERBB4, HIPK4, IRAK4, LCK, LYN, MAP2K5, MAP3K19, MKNK1, MKNK2, RIPK2, SBK1, SLK, STK10, TPTEP2-CSNK1E, Tuba1a
3
(equivalent to 1µM ≤ Kd < 10 µM)
ABCG2, ABL2, ACVR1, AKT1, AKT2, AXL, BCRP1, BLK, BRSK1, CAMK1, CAMK1D, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMKK2, CDC7, CDK1, CDK2, CDK5, CDK8, CHEK1, CHUK, CIT, CLK2, CLK4, CSF1R, CSNK1A1, CSNK1D, CSNK1G1, CSNK1G2, CSNK1G3, CSNK2A1, DAPK3, DCLK3, DMPK, DYRK1A, DYRK1B, DYRK3, DYRK4, EEF2K, EPHA1, EPHA2, EPHA3, EPHA5, EPHA8, EPHB1, EPHB4, EPHB6, FES, FGFR1, FGR, FLG, FLT3, FLT4, FRK, GRK5, GSK3A, GSK3B, HCK, HIPK2, IKBKB, IKBKE, IRAK3, JAK3, KIT, LIMK1, LTK, MAP3K2, MAP3K3, MAP4K2, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK12, MAPK13, MAPK14, MAPK4, MAPK6, MAPK8, MAPK9, MAPKAPK2, MARK2, MARK3, MARK4, MATK, MET, MINK1, MST1R, MYLK2, NEK2, NEK4, NLK, NTRK2, NUAK2, PAK4, PASK, PDK1, PDPK1, PHKG1, PHKG2, PIM1, PIM3, PIP4K2C, PKD1, PKD2, PKN2, PLK1, PLK3, PLK4, PRKAA1, PRKACA, PRKCD, PRKCG, PRKCI, PRKCZ, PRKD1, PRKD2, PRKD3, ROCK1, ROCK2, RPS6KA3, RPS6KA4, RPS6KB1, SGK2, SIK2, SRC, STK17A, STK17B, STK36, TAOK1, TBK1, TNIK, TNK2, TSSK2, TXK, Ulk3
10
(confirmed non-binding)
(Click to show)

Batch Information for HMSL10098-999-4:

HMS LINCS Batch ID: 10098-999-4
Provider:
Provider Batch ID:
Salt: 999
Molecular Formula:
Molecular Weight:
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2016-05-27
Most Recent Update: 2016-12-02