GSK461364 - Small Molecule (ID:10013-999)

HMS LINCS ID: 10013-999
Name: GSK461364
Alternative Names: GSK461364A
LINCS ID: LSM-1013
PubChem CID: 15983966
ChEBI ID:
ChEMBL ID:
Molecular Mass: 543.19
InChi: InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1
InChi Key: ZHJGWYRLJUCMRT-QGZVFWFLSA-N
SMILES: C[C@H](C1=CC=CC=C1C(F)(F)F)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)CN5CCN(CC5)C)C(=O)N
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-05-06

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
NUAK2, PLK1, STK10
2
(equivalent to 100 nM ≤ Kd < 1µM)
BMP2K, CAMK2D, CSNK2A2, FLT3, NEK2, PIM1, PIP5K1A, PKN2, PLK2, PLK3, RPS6KA3, RPS6KA4, RPS6KA6
3
(equivalent to 1µM ≤ Kd < 10 µM)
ANKK1, BRSK2, CAMK2A, CAMK2B, CAMK2G, CDK7, CSNK2A1, DAPK1, DAPK2, DAPK3, EIF2AK4, GRK4, GRK7, IRAK1, IRAK3, KIT, MAP3K1, MAP3K19, MAP3K9, MAP4K2, MERTK, NEK1, NEK5, NEK8, NEK9, NIM1K, PDGFRB, PIK3C2B, PIK3CB, PIK3CD, PIK3CG, PIM3, PIP4K2B, PIP5K1C, PRKCD, PRKCI, PRKD3, RIOK1, RIOK3, ROCK1, RPS6KA2, SLK, SRPK3, TAOK3, TIE1, ULK2
10
(confirmed non-binding)
(Click to show)

Batch Information for HMSL10013-999-4:

HMS LINCS Batch ID: 10013-999-4
Provider:
Provider Batch ID:
Salt: 999
Molecular Formula:
Molecular Weight:
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2016-05-27
Most Recent Update: 2016-12-02