GSK461364 - Small Molecule (ID:10013-101)

HMS LINCS ID: 10013-101
Name: GSK461364
Alternative Names: GSK461364A
LINCS ID: LSM-1013
PubChem CID: 15983966
ChEBI ID:
ChEMBL ID:
Molecular Mass: 543.19
InChi: InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1
InChi Key: ZHJGWYRLJUCMRT-QGZVFWFLSA-N
SMILES: C[C@H](C1=CC=CC=C1C(F)(F)F)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)CN5CCN(CC5)C)C(=O)N
Relevant Citations:
Date Publicly Available:
Most Recent Update: 2016-05-06

Nominal Targets:

Small Molecule Protein Effective Concentration Key References
GSK461364 PLK1
0.1 nM
Nat Biotechnol. 2011 Oct 30;29(11):1046-51.

Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
LINCS Compound Protein Targets and Concentrations
Nominal Targets
20031
GSK461364 KINOMEscan
KINOMEscan
20120
Metrics other than potency reveal systematic variation in responses to cancer drugs
Analysis
20268
Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates.
Analysis
20269
Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics.
Analysis
20270
Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen.
Analysis

KINOMEscan Image

Batch Information:

HMS LINCS Batch ID Provider Provider Catalog ID Provider Batch ID
10013-101-1 Haoyuan chemexpress HY-50877 HM-074_20-20101221
10013-101-2 Haoyuan chemexpress HY-50877
10013-101-3