GSK461364 - Small Molecule (ID:10013-101)
HMS LINCS ID: |
10013-101
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Name: | GSK461364 |
Alternative Names: | GSK461364A |
LINCS ID: | LSM-1013 |
PubChem CID: | 15983966 |
ChEBI ID: | |
ChEMBL ID: | |
Molecular Mass: | 543.19 |
InChi: | InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1 |
InChi Key: | ZHJGWYRLJUCMRT-QGZVFWFLSA-N |
SMILES: | C[C@H](C1=CC=CC=C1C(F)(F)F)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)CN5CCN(CC5)C)C(=O)N |
Relevant Citations: | |
Comments: | |
Date Publicly Available: | |
Most Recent Update: | 2016-05-06 |
Nominal Targets:
Small Molecule | Protein | Effective Concentration | Key References |
---|---|---|---|
GSK461364 | PLK1 | 0.1 nM | Nat Biotechnol. 2011 Oct 30;29(11):1046-51. |
Datasets:
HMS Dataset ID | Dataset Title | HMS Dataset Type |
---|---|---|
20000 | LINCS Compound Protein Targets and Concentrations | Nominal Targets |
20031 | GSK461364 KINOMEscan | KINOMEscan |
20120 | Metrics other than potency reveal systematic variation in responses to cancer drugs | Analysis |
20268 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. | Analysis |
20269 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. | Analysis |
20270 | Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. | Analysis |
KINOMEscan Image

Batch Information:
HMS LINCS Batch ID | Provider | Provider Batch ID |
---|---|---|
10013-101-1 | Haoyuan chemexpress | HM-074_20-20101221 |
10013-101-2 | Haoyuan chemexpress | |
10013-101-3 |