Alvocidib - Small Molecule (ID:10011-999)

HMS LINCS ID: 10011-999
Name: Alvocidib
Alternative Names: Flavopiridol; HMR-1275; L868275
LINCS ID: LSM-1011
PubChem CID: 5287969
ChEBI ID:
ChEMBL ID: 428690
Molecular Mass: 401.10
InChi: InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1
InChi Key: BIIVYFLTOXDAOV-YVEFUNNKSA-N
SMILES: CN1CC[C@@H]([C@@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-07-12

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
CAMKK1, CCNB1, CCNT1, CDK1, CDK19, CDK4, CDK6, CDK7, CDK9, CDKL5, DYRK1A, DYRK1B, FPGT-TNNI3K, ICK, MAK, MAP4K2, TAOK3, TNNI3K, VRK2
2
(equivalent to 100 nM ≤ Kd < 1µM)
ALK, BMPR1B, CAMKK2, CCNA1, CCNA2, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDK13, CDK14, CDK15, CDK16, CDK17, CDK2, CDK3, CDK5, CDK5R1, CDK8, CDKN3, CIT, DMPK, Dyrk1a, EIF2AK1, GAK, GRK1, GRK7, GSK3B, IRAK1, MAP2K5, MAPK15, MAPK7, PIM1, PIM2, PIM3, PIP4K2C, PRKCD, PRKCE, PRKCH, PRKCQ, PRKD1, PRKD3, STK35, TAOK1, TAOK2, TBK1, TYK2, ULK2
3
(equivalent to 1µM ≤ Kd < 10 µM)
AAK1, ABL1, ACVR1, ACVR2A, ACVR2B, ACVRL1, AXL, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CDC42BPA, CDC42BPB, CDK18, Clk1, CLK1, CLK2, CLK3, CSF1R, CSNK1A1, CSNK1A1L, CSNK1G1, DCLK1, DCLK3, DSTYK, EGFR, EIF2AK2, EPHA1, EPHA2, EPHA3, EPHA5, EPHB1, ERBB3, ERBB4, FLT3, FRK, GSK3A, HIPK1, HIPK2, HIPK3, HIPK4, IKBKE, IRAK4, JAK2, JAK3, KIT, LRRK2, LTK, MAP2K3, MAP2K4, MAP3K10, MAP3K2, MAP3K3, MAP3K7, MAP3K9, MAP4K1, MAP4K3, MAPK10, MAPK8, MERTK, MINK1, MKNK2, NUAK2, PDGFRA, PF3D7_1356900, PHKG1, PHKG2, PIP5K1C, PKD1, PKD2, PKN1, PLK4, PRKD2, PTK2B, PYGM, PYGM, ROCK1, ROCK2, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA6, RPS6KB1, SRMS, STK17A, STK17B, STK3, STK32A, STK33, TGFBR2
10
(confirmed non-binding)
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Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20193
Flavopiridol KINOMEscan
KINOMEscan

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10011-999-2