Tivozanib - Small Molecule (ID:10005-101)
HMS LINCS ID: | 10005-101 |
Name: | Tivozanib |
Alternative Names: | AV-951 |
LINCS ID: | LSM-1005 |
PubChem CID: | 9911830 |
ChEBI ID: | |
ChEMBL ID: | |
Molecular Mass: | 454.10 |
InChi: | InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28) |
InChi Key: | SPMVMDHWKHCIDT-UHFFFAOYSA-N |
SMILES: | CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)Cl |
Relevant Citations: | |
Comments: | |
Date Publicly Available: | |
Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)Target Affinity Spectrum Value | HUGO Gene Name |
---|---|
EPHB2, FLT1, FLT4, KDR, PDGFRA | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | KIT, PDGFRB |
Batch Information for HMSL10005-101-1:
HMS LINCS Batch ID: | 10005-101-1 |
Provider: | Haoyuan chemexpress |
Provider Batch ID: | HY-999-20101221 |
Salt: | 101 |
Molecular Formula: | C22H19ClN4O5 |
Molecular Weight: | 454.86 |
Purity: | |
Purification Method: | |
Chemical Synthesis Reference: | |
Comments: | |
Date Publicly Available: | 2011-07-15 |
Most Recent Update: | 2016-04-04 |
HMS QC Testing Events for HMSL10005-101-1:
Date | HMS QC Outcome | Comment | Files |
---|---|---|---|
03/13/2015 | PASS | HMSL10005-101-1_LCMS.pdf | |
02/22/2011 | PASS | None |
(Kd <100 nM)