Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| MDA-MB-134-VI | Cediranib | 10.0 | VEGFR/cKIT | RTK | -0.9999 | 0.83082 |
| MDA-MB-134-VI | Ceritinib | 10.0 | ALK | RTK | -0.9992 | 0.80386 |
| MDA-MB-134-VI | Abemaciclib | 10.0 | CDK4/6 | Cell cycle | -0.9986 | 0.81070 |
| MDA-MB-361 | Ceritinib | 10.0 | ALK | RTK | -0.9910 | 0.89628 |
| MDA-MB-361 | Taselisib | 10.0 | PI3Ka, g, d | PI3K/mTOR | -0.9902 | 0.90326 |
| MDA-MB-361 | Cediranib | 10.0 | VEGFR/cKIT | RTK | -0.9803 | 0.88037 |
| MDA-MB-361 | Torin2 | 1.0 | mTOR/ATM/ATR | PI3K/mTOR | -0.9642 | 0.85473 |
| MDA-MB-361 | Buparlisib | 10.0 | pan PI3K | PI3K/mTOR | -0.9584 | 0.84606 |
| HCC1500 | Ceritinib | 10.0 | ALK | RTK | -0.9535 | 0.74314 |
| MDA-MB-134-VI | Torin2 | 1.0 | mTOR/ATM/ATR | PI3K/mTOR | -0.9461 | 0.64780 |
| MDA-MB-134-VI | Doxorubicin | 3.1623 | Chemo | Chemotherapy | -0.9458 | 0.69164 |
| PDX1328 | Ceritinib | 10.0 | ALK | RTK | -0.9426 | 0.68787 |
| MDA-MB-361 | Taselisib | 3.1623 | PI3Ka, g, d | PI3K/mTOR | -0.9425 | 0.82696 |
| MDA-MB-361 | Vorinostat | 10.0 | HDAC | Misc | -0.9392 | 0.81668 |
| MDA-MB-361 | Pictilisib | 10.0 | pan PI3K | PI3K/mTOR | -0.9375 | 0.80430 |
| MDA-MB-157 | Ceritinib | 10.0 | ALK | RTK | -0.9264 | 0.83901 |
| PDX1328 | Topotecan | 10.0 | Topo I | Chemotherapy | -0.9128 | 0.57713 |
| MDA-MB-134-VI | Doxorubicin | 1.0 | Chemo | Chemotherapy | -0.9124 | 0.57910 |
| MDA-MB-157 | Dinaciclib | 1.0 | pan CDK | Cell cycle | -0.9106 | 0.83515 |
| HCC70 | Dinaciclib | 1.0 | pan CDK | Cell cycle | -0.9093 | 0.74283 |
| MDA-MB-157 | Dinaciclib | 0.31623 | pan CDK | Cell cycle | -0.9006 | 0.83378 |
| PDX1328 | ABT-737 | 10.0 | Bcl2/XL | Misc | -0.8967 | 0.69808 |
| HCC70 | Dinaciclib | 0.1 | pan CDK | Cell cycle | -0.8966 | 0.73612 |
| MDA-MB-134-VI | Topotecan | 10.0 | Topo I | Chemotherapy | -0.8909 | 0.42494 |
| MDA-MB-361 | Luminespib | 1.0 | HSP90 | Misc | -0.8855 | 0.74897 |