LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Trametinib | 58.33 | 12.8 | 0.0222 | 0.0223 | 0.0302 | 0.0515 | 4.3444 | 0.4024 |
| MCF 10A-H2B-mCherry | Trametinib | 60.30 | 12.8 | 0.0236 | 0.0232 | 0.0787 | 0.0863 | 5.0000 | 0.3806 |
| MCF 10A-H2B-mCherry | Trametinib | 62.27 | 12.8 | 0.0255 | 0.0246 | 0.0151 | 0.0703 | 4.3386 | 0.3770 |
| MCF 10A-H2B-mCherry | Trametinib | 64.24 | 12.8 | 0.0312 | 0.0294 | 0.0440 | 0.1264 | 5.0000 | 0.3304 |
| MCF 10A-H2B-mCherry | Trametinib | 66.21 | 12.8 | 0.0293 | 0.0275 | 0.0599 | 0.1396 | 5.0000 | 0.3328 |
| MCF 10A-H2B-mCherry | Trametinib | 68.68 | 11.8 | 0.0271 | 0.0263 | 0.0288 | 0.0625 | 5.0000 | 0.3792 |
| MCF 10A-H2B-mCherry | Trametinib | 70.65 | 11.8 | 0.0304 | 0.028 | 0.0121 | 0.1724 | 5.0000 | 0.3478 |
| MCF 10A-H2B-mCherry | Trametinib | 72.62 | 11.8 | 0.0314 | 0.0301 | -0.0207 | 0.1090 | 5.0000 | 0.3790 |
| MCF 10A-H2B-mCherry | Trametinib | 74.59 | 11.8 | Inf | Inf | 0.0817 | 0.0886 | 2.5000 | 0.3756 |
| MCF 10A-H2B-mCherry | Trametinib | 76.56 | 11.8 | Inf | Inf | -0.0241 | 0.0501 | 2.5000 | 0.4135 |
| MCF 10A-H2B-mCherry | Trametinib | 78.53 | 11.8 | Inf | Inf | -0.0282 | 0.0198 | 2.5000 | 0.4461 |
| MCF 10A-H2B-mCherry | Trametinib | 80.50 | 11.8 | Inf | Inf | -0.0324 | 0.1443 | 2.5000 | 0.3980 |
| MCF 10A-H2B-mCherry | Trametinib | 82.47 | 11.8 | Inf | Inf | -0.0247 | 0.0349 | 2.5000 | 0.5380 |
| MCF 10A-H2B-mCherry | Trametinib | 84.44 | 11.8 | Inf | Inf | 0.0511 | 0.0738 | 2.5000 | 0.5285 |
| MCF 10A-H2B-mCherry | Trametinib | 86.41 | 11.8 | Inf | Inf | -0.0396 | 0.0266 | 2.5000 | 0.5563 |
| MCF 10A-H2B-mCherry | Trametinib | 88.39 | 11.8 | Inf | Inf | 0.0264 | 0.0453 | 2.5000 | 0.6297 |
| MCF 10A-H2B-mCherry | Vorinostat | 14.50 | 11.8 | 0.9945 | 1.8329 | -0.1577 | -0.3093 | 1.2875 | 0.3330 |
| MCF 10A-H2B-mCherry | Vorinostat | 16.47 | 11.8 | 0.7307 | 0.8957 | -0.1818 | -0.1498 | 1.3691 | 0.3637 |
| MCF 10A-H2B-mCherry | Vorinostat | 18.43 | 11.8 | 0.6735 | 0.7755 | -0.1673 | -0.1097 | 1.6052 | 0.3710 |
| MCF 10A-H2B-mCherry | Vorinostat | 20.40 | 11.8 | 0.6641 | 0.7595 | -0.1413 | -0.1035 | 1.6441 | 0.3747 |
| MCF 10A-H2B-mCherry | Vorinostat | 22.37 | 11.8 | 0.7098 | 0.8298 | -0.1346 | -0.1146 | 1.6857 | 0.3643 |
| MCF 10A-H2B-mCherry | Vorinostat | 24.34 | 11.8 | 0.6895 | 0.8517 | -0.1645 | -0.1500 | 1.6640 | 0.3608 |
| MCF 10A-H2B-mCherry | Vorinostat | 26.31 | 11.8 | 0.6733 | 0.833 | -0.1566 | -0.1645 | 1.5542 | 0.3821 |
| MCF 10A-H2B-mCherry | Vorinostat | 28.28 | 11.8 | 0.7604 | 0.9676 | -0.1673 | -0.1921 | 1.4783 | 0.3771 |
| MCF 10A-H2B-mCherry | Vorinostat | 30.24 | 11.8 | 0.863 | 1.124 | -0.2015 | -0.2266 | 1.4654 | 0.3633 |