LINCS MCF 10A Common Project: Highly-multiplexed imaging by Cyclic Immunofluorescence (CycIF) of protein levels and protein phosphorylation states in the MCF 10A breast cell line treated with 8 small molecule perturbagens. Dataset 4 of 6: Nuclear fluorescent intensity measurements at 48 hr. - Dataset (ID:20306)

Proteins Studied

  • 23 Proteins
LINCS ID Name HMS LINCS ID UniProt ID Alternative Names Provider Mutation Phosphlorylation State Domain Protein Description
201350 FOXO3a 201350 O43524
Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1
200507 EGFR 200507 P00533
Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
201409 c-Myc 201409 P01106
Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64
200543 p53 200543 P04637
Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53
201297 Rb (pS807; pS811) 201297 P06400 pS807; pS811
201336 Rb (pS811) 201336 P06400 pS811
201335 Rb (pS807) 201335 P06400 pS807
201302 PCNA 201302 P12004
Proliferating cell nuclear antigen; Cyclin
201406 RP-A p32 201406 P15927
Replication protein A 32 kDa subunit; Replication factor A protein 2; RF-A protein 2; Replication protein A 34 kDa subunit; RP-A p34
201314 H2A.X (pS139) 201314 P16104 pS139
201351 Cyclin-D1 201351 P24385
G1/S-specific cyclin-D1; B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene
201361 Cyclin-E1 201361 P24864
G1/S-specific cyclin-E1
201337 ERK-1 (pT202) 201337 P27361 pT202
201303 ERK-1 (pT202; pY204) 201303 P27361 pT202; pY204
201338 ERK-2 (pT185) 201338 P28482 pT185
201304 ERK-2 (pT185; pY187) 201304 P28482 pT185; pY187
201295 p21 201295 P38936
Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6
201296 KI-67 201296 P46013
Antigen KI-67
201344 p27Kip1 201344 P46527
Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27
201298 S6 (pS235; pS236) 201298 P62753 pS235; pS236
201294 H3 (pS10) 201294 P68431 pS10
201407 E2F-1 201407 Q01094
Transcription factor E2F1; PBR3; Retinoblastoma-associated protein 1; RBAP-1; Retinoblastoma-binding protein 3; RBBP-3; pRB-binding protein E2F-1
201408 FOXO1a 201408 Q12778
Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma
  • 23 Proteins