Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

Data Columns

  • 17 Data Columns
Name Description Display Name Data Type Unit Precision Readout Type Replicate Comments
antibody
Antibody perturbagen
Antibody antibody
gRinf
Asymptotic value (concentration = infinity) for the sigmoidal curve fit to the dose-response data
GRinf Numeric 4
cell
Cell reagent
Cell cell
clinicalSubtype
Clinical subtype of cell line
Clinical Subtype Text
concUnit
Concentration unit for GR50 and GEC50
Conc Unit Text
nominalDivisionRate
Estimated number of divisions of the DMSO-treated control over the course of the assay
Nominal Division Rate Numeric 4
gRAOC
Integral of GR(c) over the range of concentrations tested
GR_AOC Numeric 4
gRHillCoefficient
Maximal slope of the dose-response curve
GR Hill Coefficient Numeric 4
gRmax
Normalized growth inhibition rate at the highest tested perturbagen concentration
GRmax Numeric 4
gR50
Perturbagen concentration at which GR(c)=0.5
GR50 Text
gEC50
Perturbagen concentration that results in 50% efficacy
GEC50 Text
gRR2
r^2 for the sigmoidal curve fit to the dose-response data
GR r2 Text
smallMolecule
Small molecule perturbagen
Small Molecule small_molecule
transcriptionalSubtype
Transcriptional subtype of cell line
Transcriptional Subtype Text
perturbagenTarget Perturbagen Target Text
perturbagenClass Perturbagen Class Text
biologicalReplicateID Biological Replicate ID Text
  • 17 Data Columns