Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Gefitinib | MCF 10A | 0 (control) | 24 | hr | 295.80 | 110.01 | p-Akt | 55.06 | | |
| Torkinib | MCF 10A | 0 (control) | 6 | hr | 498.87 | 147.67 | p-Akt | 54.88 | | |
| Torkinib | MCF 10A | 0 (control) | 24 | hr | 335.16 | 114.92 | p-Akt | 54.49 | | |
| GSK1059615 | MCF 10A | 0 (control) | 6 | hr | 450.57 | 164.32 | p-Akt | 55.84 | | |
| GSK1059615 | MCF 10A | 0 (control) | 24 | hr | 372.12 | 121.72 | p-Akt | 53.36 | | |
| MK2206 | MCF 10A | 0 (control) | 6 | hr | 475.25 | 162.73 | p-Akt | 59.87 | | |
| MK2206 | MCF 10A | 0 (control) | 24 | hr | 334.53 | 120.26 | p-Akt | 52.16 | | |
| Triciribine | MCF 10A | 0 (control) | 6 | hr | 477.54 | 163.37 | p-Akt | 60.15 | | |
| Triciribine | MCF 10A | 0 (control) | 24 | hr | 333.49 | 112.55 | p-Akt | 47.91 | | |
| Dactolisib | MCF 10A | 0 (control) | 6 | hr | 436.72 | 165.98 | p-Akt | 55.27 | | |
| Dactolisib | MCF 10A | 0 (control) | 24 | hr | 351.94 | 125.18 | p-Akt | 50.36 | | |
| Gefitinib | T47D | 0 (control) | 6 | hr | 176.65 | 97.90 | p-Akt | 103.18 | | |
| Gefitinib | T47D | 0 (control) | 24 | hr | 177.88 | 116.19 | p-Akt | 85.23 | | |
| Torkinib | T47D | 0 (control) | 6 | hr | 192.56 | 91.57 | p-Akt | 104.03 | | |
| Torkinib | T47D | 0 (control) | 24 | hr | 176.46 | 94.89 | p-Akt | 74.20 | | |
| GSK1059615 | T47D | 0 (control) | 6 | hr | 168.92 | 88.95 | p-Akt | 95.10 | | |
| GSK1059615 | T47D | 0 (control) | 24 | hr | 168.24 | 91.00 | p-Akt | 67.96 | | |
| MK2206 | T47D | 0 (control) | 6 | hr | 102.66 | 35.62 | p-Akt | 15.31 | | |
| MK2206 | T47D | 0 (control) | 24 | hr | 176.28 | 99.14 | p-Akt | 70.51 | | |
| Triciribine | T47D | 0 (control) | 6 | hr | 109.11 | 47.87 | p-Akt | 21.01 | | |
| Triciribine | T47D | 0 (control) | 24 | hr | 186.87 | 92.32 | p-Akt | 71.34 | | |
| Dactolisib | T47D | 0 (control) | 6 | hr | 99.23 | 26.75 | p-Akt | 14.05 | | |
| Dactolisib | T47D | 0 (control) | 24 | hr | 165.27 | 86.01 | p-Akt | 60.10 | | |
| Gefitinib | AU565 | 1.0 | nM | 6 | hr | 297.48 | 65.22 | p-Akt | 31.78 | |
| Gefitinib | AU565 | 1.0 | nM | 24 | hr | 556.22 | 122.40 | p-Akt | 136.15 | |