Cetuximab - Antibody (ID:80078)
| HMS LINCS ID: | 80078 |
| Name: | Cetuximab |
| Alternative Names: | Erbitux |
| Clone Name: | |
| Resource Identification Initiative ID: | |
| LINCS ID: | |
| Type: | engineered |
| Nominal Protein Target(s): | EGFR |
| Nominal Protein Target HMS LINCS ID(s): | 200507 |
| Nominal Non-protein Target: | |
| Organism of Nominal Target: | Homo sapiens |
| Other Target Information: | binds specifically to the extracellular domain of human EGFR (source: Bristol-Myers Squibb) |
| Other Human Protein Target HMS LINCS ID(s): | |
| Immunogen: | |
| Immunogen Sequence: | |
| Fc Domain Source Species: | human |
| Clonality: | monoclonal |
| Fc Domain Isotype: | IgG1 |
| Source Organism for Production: | murine myeloma cells |
| Production Details: | recombinant, human/mouse chimeric monoclonal antibody (chimerized from mouse monoloclonal antibody 225); composed of the Fv regions of the murine anti-EGFR antibody with human IgG1 heavy and kappa light chain constant regions; produced in mammalian (murine myeloma) cell culture (source: Bristol-Myers Squibb) |
| Conjugate or Label: | |
| Labeling Details: | |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | 2016-09-16 |
| Most Recent Update: | 2016-09-16 |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20268 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. | Analysis |
| 20269 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. | Analysis |
| 20270 | Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. | Analysis |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Catalog ID | Provider Batch ID |
|---|---|---|---|
| 80078-1 | Bristol-Myers Squibb |